Results
| PMID | 10360259 |
| Gene Name | IGF1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 44 |
| Population details | 44 (29 patients with endometriosis (15 in stage I & II endometriosis, 14 stages III & IV endometriosis), 15 controls) |
| Sex | Female |
| Associated genes | IGFI, IGFII, IGFBP3 |
| Other associated phenotypes |
Endometriosis |
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J Reprod Med. 1999 May;44(5):450-4. Gurgan, T| Bukulmez, O| Yarali, H| Tanir, M| Akyildiz, S Department of Obstetrics and Gynecology, Hacettepe University School of Medicine, Ankara, Turkey. OBJECTIVE: To examine whether insulinlike growth factor I (IGF I), IGF II and IGF binding protein 3 (IGFBP 3) in serum and peritoneal fluid (PF) correlate with the presence and severity of endometriosis. STUDY DESIGN: Case-control study including 29 patients with endometriosis and 15 controls. The revised American Fertility Society classification stages of I and II were pooled as early-stage (n = 15), and stages III and IV were taken as late stage (n = 14). Simultaneous sampling of blood and PF was performed during laparoscopy, and IGF I, IGF II and IGFBP 3 levels were determined by immunoradiometric assay. RESULTS: The serum levels of all three proteins were higher than PF levels except for a reversed IGF I PF: serum ratio in the early stage. There were no significant differences in IGF II and IGFBP 3 levels among the groups. The mean serum IGF I levels of controls and early-stage patients were significantly lower than those in the late stage. Also, mean PF IGF I levels in controls were significantly lower than in the late stage. CONCLUSION: IGF I may be an important mediator in the development and/or maintenance of endometriosis or progression to late-stage disease. Mesh Terms: Adult| Ascitic Fluid/immunology| Case-Control Studies| Disease Progression| Endometriosis/immunology/*pathology| Female| Humans| Inflammation/immunology| Insulin-Like Growth Factor Binding Protein 3/*analysis| Insulin-Like Growth Factor I/*analys |
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